Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013115
Fusion event
HBV-FAM174A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr5
Cytoband
q21.1
Reference genome
End
99902803/100567099 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10397/Upstream/4487887; hsa-mir-103a-1/Downstream/249383;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/31083, chr5-CpG: 32/Downstream/333764
Upstream sequence
gagaccagactggccaacatggtgaaacaccttccctactaaaaatacaaaaattaccctggcgtggtgatgggcacctgtagtcccagctactcgagag
Downstream sequence
AAGTGAAAGAACAAGAATTGGTTATAATAATGGTAAAGCATGTTTCAGGGATAAGAATGAAATCATCTTGAGTTATTTAGTAATCTGACCCAATTTACTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.