Basic Information
VIS ID
TVIS10013117
Fusion event
HBV-LOC107984041 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
198
Orient
+
Integrated sequence
GACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTG| |TTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGT
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
101563392/101115516 (Hg38)
End
101563392/101115516 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107984041
Nearest miRNA
hsa-mir-10398/Upstream/1990820; hsa-mir-1202/Downstream/5668609;
Nearest TSS
ENST00000381078/Upstream/234045; ENST00000358361/Downstream/283272;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/233941, chr6-CpG: 36/Downstream/278033
Nearby gene
ASCC3(-234168) ; GRIK2(+283469) ;
Upstream sequence
ctttctgttAAAGAAAAATTGTATTATTTAATTTTGATAGAGAGACATTGTTAATTAGATTGGGATGTTGTGTATGATTCTCTCTTAGGTGTAAAAGCTT
Downstream sequence
GGGGTGCGTGGTAGAAACCATTATCTTTTGAATCATACATTCAGTCAATTAGTCAGGTaacaaatatttattgaactaccatgtgtcaagtattgtttaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate