Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013118
Fusion event
HBV-IGF2R integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
End
160502968/160081936 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-657 ; hsa-mir-155-5p ; hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-1271-5p ; hsa-mir-423-3p ; hsa-mir-128-3p ; hsa-mir-211-5p ; hsa-mir-545-5p ; hsa-mir-412-3p ; hsa-mir-377-3p ; hsa-mir-218-5p ; hsa-mir-96-3p ; hsa-mir-2681-3p ; hsa-mir-548m ; hsa-mir-8485 ; hsa-mir-7977 ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-564 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-383-3p ; hsa-mir-342-3p ; hsa-mir-6777-3p ; hsa-mir-6089 ; hsa-mir-561-5p ; hsa-mir-6715b-3p ; hsa-mir-4742-3p ; hsa-mir-6715a-3p ; hsa-mir-1178-5p ; hsa-mir-649 ; hsa-mir-106a-3p ; hsa-mir-1296-5p ; hsa-mir-6877-5p ; hsa-mir-4480 ; hsa-mir-5008-5p ; hsa-mir-3146 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4512 ; hsa-mir-6895-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-1247-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-3612 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4756-3p ; hsa-mir-5186 ; hsa-mir-5694 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-4252 ; hsa-mir-4719 ; hsa-mir-551b-5p
Nearest miRNA
hsa-mir-10398/Upstream/1317183; hsa-mir-1913/Downstream/6427418;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/75466, chr6-CpG: 43/Downstream/8968
Nearest cancer related gene
IGF2R(TSG, No orient, 0)
Upstream sequence
atatttaatgtgtacaatttgacatatttggacatatacatatacccataaaaccattacaacaatcgagataatgagtacatcacccccagtagattct
Downstream sequence
tgcagttaatgcaatcatcacagggtcctgaggcgacatacatcctcagcttacgaagatgatgggattaagagattaaagtaaagacaggcataggaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.