Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013120
Fusion event
HBV-LMBRD1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2216
Orient
+
Integrated sequence
TGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACAT| |TTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCT
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
Start
End
70400288/69690396 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10398/Upstream/12300184; hsa-mir-10524/Downstream/1686564;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1055242, chr6-CpG: 53/Downstream/106004
Upstream sequence
TAATTACCTCTTAAATCTTTATTTGCCTAGCATTTTAAGATTTTCATTTTCAGACTTTTTGTTATTTATAAAGCAGAGATATTGAGTTATTTAAGAAAAA
Downstream sequence
AGATAGATGGAATAAAGAATACAATTACTTTGCAAAAAGACTCAAGAGGAATTAGCCAACAAGAAATCTCCTGAATGCTGTTCAGTAAGATTCCATATGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.