Basic Information
VIS ID
TVIS10013125
Fusion event
HBV-LOC105375147 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
342
Orient
-
Integrated sequence
GCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCA| |ACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGG
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
9947401/9907772 (Hg38)
End
9947401/9907772 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375147
Nearest miRNA
hsa-mir-339/Upstream/2840727; hsa-mir-10399/Downstream/8219448;
Nearest TSS
ENST00000635602/Upstream/170450; ENST00000451755/Downstream/53252;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/181186, chr7-CpG: 31/Downstream/871906
Nearby gene
PER4(-271954) ; NDUFA4(+1024179) ;
Upstream sequence
cacagccaaattctaccagacgtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcactt
Downstream sequence
ggctattctggatgtgttgtggtttctttttttttttagaattgtttttctatttctgtgaagaaagtgattggtattgtcacattgaatctgtagattg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate