Basic Information
VIS ID
TVIS10013127
Fusion event
HBV-ZFHX4-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1974
Orient
+
Integrated sequence
CAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTT| |CCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAG
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77536053/76623818 (Hg38)
End
77536053/76623818 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
ZFHX4-AS1
Nearest miRNA
hsa-mir-124-1/Upstream/1918071; hsa-mir-10400/Downstream/342950;
Nearest TSS
ENST00000518652/Upstream/7377; ENST00000523885/Downstream/57401;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1215629, chr8-CpG: 59/Downstream/58202
Upstream sequence
agagtctgcatttttatgcggctcccaggtgataccaatgctgcagatgcacagaccacactttgagtggtaagACTGAAGACTACATAGTTGTCATTGT
Downstream sequence
ATATACAGAATCAAACAGAACATTTTCATAAGACAGATATGATTTTTACATTAAAAAAATAAAACTTGCCCTAGTTAATTCTTCCTGAAAGTGTTGGATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate