VISDB Viral Integration Site DataBase

VIS ID

TVIS10013130

Fusion event

HBV-TLR4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1683

Orient

-

Integrated sequence

CACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAAT| |GTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGC

Chromosome

chr9

Cytoband

q33.1

Reference genome

Start

End

120478443/117716165 (Hg38)

Orient

+

Location type

UTR3

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7i-5p ; hsa-mir-146a-5p ; hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-146b-5p ; hsa-let-7b-5p ; hsa-mir-526b-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-1468-3p ; hsa-mir-4698 ; hsa-mir-4694-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-3658 ; hsa-mir-4279 ; hsa-mir-630 ; hsa-mir-4738-3p ; hsa-mir-942-5p ; hsa-mir-4742-3p ; hsa-mir-548g-3p ; hsa-mir-26b-5p ; hsa-mir-181b-2-3p

Nearest miRNA

hsa-let-7a-1/Upstream/3506636; hsa-mir-12126/Downstream/2528814;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/300947, chr9-CpG: 44/Downstream/28784

Upstream sequence

ttttgtaataagtgtgatgtggtgctgagaagaatgtatattctattgatttggggtggagagttctgtagatgtctattatgtctgcttggtgcagagc

Downstream sequence

aaaatagaactgctatatgatccagcaatctcacttctgtatatatacccaaaataattgaaatcagaatttcaagaaaatatttacactcccatgttca