Basic Information
VIS ID
TVIS10013133
Fusion event
HBV-LOC101928832 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chrX
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
145997672/146916154 (Hg38)
End
145997672/146916154 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRAXA
Target gene
LOC101928832
Nearest miRNA
hsa-let-7f-2/Upstream/888282; hsa-mir-105-1/Downstream/273550;
Nearest TSS
ENST00000429181/Upstream/101428; ENST00000639829/Downstream/264910;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/295391, chrX-CpG: 91/Downstream/995419
Nearby gene
CXorf51A(-101423) ; MIR506(+314566) ;
Upstream sequence
agcctggggctaggggaggaatattccagcactctcttagccaccccagctggtgtctcagtaggttatgtgttgtccgcagactcctggttctgggccc
Downstream sequence
tgcagttaatgcaatcatcacagggtcctgaggcgacatacatcctcagtttatgaagatgacaggattaagagattaaagcaaagacagacacaggaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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