Basic Information
VIS ID
TVIS10013135
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
22
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAA| |CTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTC
Host Sequence
Chromosome
chrX
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
26586957/26568840 (Hg38)
End
26586957/26568840 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/6551653; hsa-let-7f-2/Downstream/1926715;
Nearest TSS
ENST00000429181/Upstream/10503; ENST00000580017/Downstream/590153;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/10785, chrX-CpG: 28/Downstream/1294997
Nearby gene
VENTXP1(-7788) ; PPP4R3C(+891371) ;
Upstream sequence
tgcttggatctcatgccagaataaattcaaggtgagtctcaaagtatagtgaaaagagatggtttattaaaagctactccattacagagtagggcatcct
Downstream sequence
acctattgtactatcaaaaagtagtgcttattccttttatctgactgtatttttgtacccattaacccacccctttttactccccactaccattcccagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate