Basic Information
VIS ID
TVIS10013155
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1601
Orient
-
Integrated sequence
TCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTG| |CACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGA
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64979913/64114195 (Hg38)
End
64979913/64114195 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/3191511; hsa-mir-1243/Downstream/2162629;
Nearest TSS
ENST00000502981/Upstream/619917; ENST00000509473/Downstream/167341;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/764329, chr4-CpG: 32/Downstream/1555280
Nearby gene
TECRL(+164264) ;
Upstream sequence
gatatctacccaaagggaaataagtcattacatcaaaaagacacctacatgcatctgtttattgcagcacaatttcaaagatatggaaccaatctaagta
Downstream sequence
TTAGGAGAAAACATATGAGAGATTAGGAAGCTTCTTTTAGCTCTTTCTTGATATGCTTTTTGATATCGTGGTCACAGAAAAGGCATCCTGGCTCATAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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