EYS _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013162
Fusion event
HBV-EYS integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
21
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAA| |ACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGT
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
66414213/65704320 (Hg38)
End
66414213/65704320 (Hg38)
Orient
+
Location type
Intronic
Target gene
EYS
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-510-3p ; hsa-mir-376a-5p ; hsa-mir-4680-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-mir-10398/Upstream/8314108; hsa-mir-10524/Downstream/5672640;
Nearest TSS
ENST00000381078/Upstream/208322; ENST00000449928/Downstream/2894;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/402732, chr6-CpG: 34/Downstream/83462
Upstream sequence
attTTAAAAAAACGTAATTTTTAAAGGCTTGAAAATTCTCAATATTTGGAGAAAAACAAAATAAAAGCATGTGTACATTATTTTAAAGCAAATTTGTCTC
Downstream sequence
tatgaaaattcacttgctaaaaactgcaaagttaatgagtaacagactaatagtcttaaaccactgtgtctgacttcagagcccatgctcGATTACTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate