Basic Information
VIS ID
TVIS10013176
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2387
Orient
+
Integrated sequence
CTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTC| |GCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTAC
Host Sequence
Chromosome
chr1
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
191350698/191381568 (Hg38)
End
191350698/191381568 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/10943178; hsa-mir-1182/Downstream/1334760;
Nearest TSS
ENST00000473358/Upstream/153101; ENST00000430776/Downstream/485392;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4700619, chr1-CpG: 56/Downstream/1426934
Nearby gene
LINC01720(-579910) ; RGS18(+776894) ;
Upstream sequence
acaatcttttatcttaacctgaacatttcctttctagctatcccaggtcttcagataaactcaaccaactataaaccagaaaatgtttaaatttacctat
Downstream sequence
agcctggaagtccccccaccccctgcgctttgagttgtcccacctttctgaatcaaatccatgtattattaaatgtatttgattgatgtcgcatggctct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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