VISDB Viral Integration Site DataBase

VIS ID

TVIS10013179

Fusion event

HBV-RYR2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1824

Orient

-

Integrated sequence

TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG

Chromosome

chr1

Cytoband

q43

Reference genome

Start

End

237530934/237367634 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-let-7c-5p

Nearest miRNA

hsa-mir-101-1/Upstream/1514574; hsa-mir-3123/Downstream/103485;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/324290, chr1-CpG: 22/Downstream/416253

Upstream sequence

TAATAAAAAGGTTGTAATAATATTGGATAttaaagcatctttctgtacttcttaaggcacaggtcagtatcatcactcttattctgaaaatttttaaaga

Downstream sequence

cctccttttcctgcaaaAAGAATTACAAACTTCTCGTCATAATATTTTGTACCTTCCATGGTCTTTCCCTGATCTAATTTTATAATTCCTGTGAAGTTTT