Basic Information
VIS ID
TVIS10013182
Fusion event
HBV-LOC112268263 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
706
Orient
+
Integrated sequence
CCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCG| |TAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACC
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
59181549/58715877 (Hg38)
End
59181549/58715877 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
LOC112268263
Nearest miRNA
hsa-mir-12136/Upstream/3490154; hsa-mir-101-1/Downstream/1017350;
Nearest TSS
ENST00000473358/Upstream/268; ENST00000636386/Downstream/2543;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/138254, chr1-CpG: 271/Downstream/65912
Nearby gene
MYSM1(-15802) ; JUN(+64914) ;
Upstream sequence
AGCAGTGCATTTTTATTGTTTTATTAATGCAAACAAAAAATTTTATAAGAGCTTTTGTATAATCATTCCTTACTTCACTACCTTATTTACTCTTAAGGAC
Downstream sequence
TTAACTACAAATACTCTCGCAAGGAGGGTGGTGCTTTTGGGTTTGAACGGGAATTTCAAACCTCTTTACTTTAGCATTGTCTGTCTCTTGTCTTATGTAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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