Basic Information
VIS ID
TVIS10013183
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1728
Orient
-
Integrated sequence
CCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAA| |AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
655252/719872 (Hg38)
End
655252/719872 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
OR4F16 ; SEPTIN14P14
Nearest miRNA
hsa-mir-12136/Upstream/87187; hsa-mir-101-1/Downstream/447232;
Nearest TSS
ENST00000473358/Upstream/33199; ENST00000422528/Downstream/41039;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/108603, chr1-CpG: 60/Downstream/58732
Nearby gene
OR4F16(-33218) ; LOC100133331(+5887) ;
Upstream sequence
tgttggtcaggctggtctcgaactcctaacctcaggtagtcgacccacctcggcctcccacagtgctgagattacaggcatgagccaccacgccctgcta
Downstream sequence
ggagttcacgctttagttggggaaaatatacaataagcaagccagtttttaaaatgagaactgcaattagagttaaatgctacaaagacaaactcacagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate