Basic Information
VIS ID
TVIS10013184
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1681
Orient
-
Integrated sequence
TGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCA| |ATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAG
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
End
75408338/74942654 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-101-1/Upstream/3874938; hsa-mir-11399/Downstream/2117489;
Nearby gene
TYW3(-175978) ; LHX8(+185781) ;
Upstream sequence
ATTTTAAGTTTTTCTTGAATAATTGCTTTGATTCTAAAATTTTCATCAATGACATCTGTTCCAGGTTATAGAAATGTCTAACCTGAGATGAATGCTAATG
Downstream sequence
AAAAAAGAGGTCAAGAAATGTTTCCACTTAGAGCTGGCCACAGAGTAGGGAATGTTATACAGATCAAGAGATTCCATTTGGCCTCAGAAAGACCATGGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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