Basic Information
VIS ID
TVIS10013192
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2412
Orient
+
Integrated sequence
CCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCG| |CCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCT
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
28640789/28351860 (Hg38)
End
28640789/28351860 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/62510; hsa-mir-107/Downstream/1193144;
Nearest TSS
ENST00000439456/Upstream/17374; ENST00000526722/Downstream/143953;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/48672, chr10-CpG: 177/Downstream/180400
Nearby gene
MPP7(-69722) ; WAC-AS1(+168057) ;
Upstream sequence
gctgcttcaaatatagcgatgtgcagaaatttcctgcagcaaacagtgaagttaCCTACTGATTACAGTCTTTTCCTGGGGCAACAACTAAGCAGTGCTG
Downstream sequence
AATTGGGCATTTCCCAGAACGAACAACTAAGCCATGCTGAATTGGGTATTTACATACTCAGTCTTTAGCCTTAAATTCTCTCTCTCTCTCCCCCTTTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate