Basic Information
VIS ID
TVIS10013203
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
+
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
108461649/108067872 (Hg38)
End
108461649/108067872 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/3476156; hsa-mir-1178/Downstream/567938;
Nearest TSS
ENST00000382841/Upstream/203310; ENST00000546811/Downstream/61599;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/163906, chr12-CpG: 50/Downstream/61312
Nearby gene
LOC728739(-164101) ; WSCD2(+61862) ;
Upstream sequence
tcattgcaacctcagcctcctgggttcaagcaattcttcttcctcagcctcccgagtagctgggactacaggcgtgtgccaccatgccctgctaattttt
Downstream sequence
gtatttttagtagagacggggtttcaccatactggccaggctgatcttgaactcctgacctcgtgatttgcccaccttggcctcccaaagtgctggaatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate