PTPRO _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013207
Fusion event
HBV-PTPRO integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
936
Orient
+
Integrated sequence
AACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAA| |TCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACA
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
15747985/15595051 (Hg38)
End
15747985/15595051 (Hg38)
Orient
+
Location type
UTR3
Target gene
PTPRO
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-26b-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2679133; hsa-let-7i/Downstream/2078248;
Nearest TSS
ENST00000382841/Upstream/14288; ENST00000544706/Downstream/170;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/272084, chr12-CpG: 104/Downstream/193733
Upstream sequence
ATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCC
Downstream sequence
GGAGCAGTAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAGAGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTTGTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate