Basic Information
VIS ID
TVIS10013210
Fusion event
HBV-RXYLT1-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1811
Orient
-
Integrated sequence
AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr12
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
64209695/63815915 (Hg38)
End
64209695/63815915 (Hg38)
Orient
-
Location type
Intronic
Target gene
RXYLT1-AS1
Nearest miRNA
hsa-let-7i/Upstream/1212146; hsa-mir-10527/Downstream/7748;
Nearest TSS
ENST00000382841/Upstream/10964; ENST00000542381/Downstream/6241;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/35457, chr12-CpG: 45/Downstream/5804
Nearby gene
RXYLT1(-6808) ; SRGAP1(+28846) ;
Upstream sequence
atattttgttcatcatggattattttacattacttttggtggtagtaattgcatgaaaatatcactcaccttgattactatgctgtttggcaccccctga
Downstream sequence
agcttgccccaatgagagtcctttactctcagcaccctagtcctggccTGATAATAAGCAACCTCAATATCTCAGTGGCGTACAAAAACAGACATGTATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate