Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013211
Fusion event
HBV-NR2C1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1822
Orient
+
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
Start
End
95452925/95059149 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7i/Upstream/224636; hsa-mir-1178/Downstream/249271;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/55314, chr12-CpG: 102/Downstream/13725
Upstream sequence
ctagcactttgggaggccaaggcaggtggatcacttgaggtcaggagttcaagaccagcatggccaacatggcaaaagcccgtctctactgaaaatacaa
Downstream sequence
aaattagcagggcatggtggcacacgcctgtagtcccagctactcagaaggccgaggcaggagaattgcttgaacccaggaggcagaggttgcagtgagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.