Basic Information
VIS ID
TVIS10013214
Fusion event
HBV-LOC105370213 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2156
Orient
-
Integrated sequence
ATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGT| |AGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTAT
Host Sequence
Chromosome
chr13
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
55414370/54840235 (Hg38)
End
55414370/54840235 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105370213
Nearest miRNA
hsa-mir-1297/Upstream/528187; hsa-mir-1267/Downstream/334219;
Nearest TSS
ENST00000623511/Upstream/707369; ENST00000616396/Downstream/100608;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1638025, chr13-CpG: 25/Downstream/2300602
Nearby gene
MIR1297(-528187) ; MIR5007(+334219) ;
Upstream sequence
ATGAAAGCAAATGGAAAAGGTAGGTAAAAGATATTTACTAGAATATTGTTGAAGAAATCAATATACAAAATATCAAATTTTGAAGCAATCTTTCCCacct
Downstream sequence
cactagtaatcataaaataaatattaagccataataaaatattattttaaactcatcataccaagaaaaataaccgaagttgggcagtttttagttggtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate