Basic Information
VIS ID
TVIS10013220
Fusion event
HBV-LOC105371256 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
51399770/51365859 (Hg38)
End
51399770/51365859 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105371256
Nearest miRNA
hsa-mir-1225/Upstream/623482; hsa-mir-11401/Downstream/4879661;
Nearest TSS
ENST00000527434/Upstream/1759; ENST00000565308/Downstream/159288;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/209510, chr16-CpG: 125/Downstream/1179865
Nearby gene
SALL1(-214587) ; C16orf97(+660494) ;
Upstream sequence
atttcctatattcccatctagaagttatgctccatgagaagggTCAGTATGTTGTGCAATTCCAAGGACACTAATCACAAAGAACACAATGCAATTGCTG
Downstream sequence
CCTCCTGCATTGTATAATCTGGTAATCTTGtctgtaagagcagtgacctcctctgtactgttcacctccatggccccgtgcctagaatggtacatggcac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate