Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013227
Fusion event
HBV-LRRC37A3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1756
Orient
-
Integrated sequence
TAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATT| |AGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATG
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
Start
End
62864570/64868452 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-10226/Upstream/46350; hsa-mir-1250/Downstream/1918620;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/31042, chr17-CpG: 85/Downstream/50612
Upstream sequence
aatgttactatatgaaaattatacctcaatgaacctgacttaagaaaaTAATAAAACAAACCTAAAGAAACAACTACGTAAAAATAAATCTCGGAAAAAA
Downstream sequence
ATAACTTACAGTTTTTCCAGTTCAACAGTCATCATGAGAATGTTCTTAAGTGTTGTAAGTGGGACTAGCGTTGTTCCCATGTCTCTGAAGAAGAAAGCCG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.