VISDB Viral Integration Site DataBase

VIS ID

TVIS10013230

Fusion event

HBV-SPEM1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1822

Orient

+

Integrated sequence

GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA

Chromosome

chr17

Cytoband

p13.1

Reference genome

Start

End

7325515/7422196 (Hg38)

Orient

+

Location type

downstream

Target gene

miRNAs that regulate target gene

hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-150-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-4698 ; hsa-mir-186-3p ; hsa-mir-1227-3p ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-30b-3p ; hsa-mir-3192-5p ; hsa-mir-3612 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-455-3p ; hsa-mir-4728-5p ; hsa-mir-490-3p ; hsa-mir-550b-2-5p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6799-5p ; hsa-mir-6807-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-7851-3p

Nearest miRNA

hsa-mir-1253/Upstream/198817; hsa-mir-10226/Downstream/665860;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/4570, chr17-CpG: 163/Downstream/13579

Upstream sequence

cactgcaacctctgcctcccaggttcaaccaattctcctgccttcagcctcctgagtagctgggactacaggcgtgtgccaccatgccctgctaattttt

Downstream sequence

gtatttttagtgcagatggggttttgccatgtcggccaggctggtcttgaactcctgacctcaggtgatccgcccgcctcagcctcccaaagtgctggga