Basic Information
VIS ID
TVIS10013231
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
332
Orient
+
Integrated sequence
TCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA| |TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC
Host Sequence
Chromosome
chr19
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
13760660/13649846 (Hg38)
End
13760660/13649846 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-10395/Upstream/709306; hsa-let-7e/Downstream/186441;
Nearest TSS
ENST00000633603/Upstream/16821; ENST00000587098/Downstream/81914;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/143393, chr19-CpG: 52/Downstream/52601
Nearby gene
CACNA1A(-143386) ; CCDC130(+98093) ;
Upstream sequence
aaagcaacgccactcttctcactaaatttttttttaaatataataaaatatattcattgtgttaggctgggcgcggtggctcacgcctgtaatcccacta
Downstream sequence
ctttgggaggctaaggcaggtggatcacctgagatcaggagttcgagaccagcctggccaacatggtgaaaccccgtctctactaaaatacaaaaaatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate