Basic Information
VIS ID
TVIS10013233
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3085
Orient
-
Integrated sequence
AGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGC| |AAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30583524/30092617 (Hg38)
End
30583524/30092617 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/9693263; hsa-let-7e/Downstream/5030083;
Nearest TSS
ENST00000633603/Upstream/62701; ENST00000590564/Downstream/135673;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/149659, chr19-CpG: 51/Downstream/129884
Nearby gene
URI1(-76005) ; ZNF536(+279804) ;
Nearest cancer related gene
URI1(OG, -76005) ;
Upstream sequence
TATTTACATCTTTTGTTGATATTTTTTATAGATTAAAAGCGCCTCTTTGCTAGGTGATAATTCTGCTAAGTACTGTAATTTGCTGCCATTAATATTTGTC
Downstream sequence
TGAGTCCTAGTTTGCAAAATATATTTGAAACCACGTTAGAAAGTCGCATAATTGCTTCTTTAAGCTGGGGAAATAAGCAGTTTCTTTACCCAGCCTTTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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