Basic Information
VIS ID
TVIS10013237
Fusion event
HBV-MZF1-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2713
Orient
+
Integrated sequence
TGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAA| |CATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTT
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
59082851/58571484 (Hg38)
End
59082851/58571484 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA19A
Target gene
MZF1-AS1
Nearest miRNA
hsa-let-7e/Upstream/21108;
Nearest TSS
ENST00000633603/Upstream/6871; ENST00000595245/Downstream/61;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8096, chr19-CpG: 80/Downstream/1350
Upstream sequence
CTCATAGAGGGTACCAGGTCAGGTATCTGAGGCCAGTGTCTGCCCCTGGTGAAGAAATAGGATGAGGCTGTTGCAAAAGGAGTACAGTGAATGCTTCACT
Downstream sequence
GCCTAGTCTATGCTGTACCGTTTGATCCTCAGACCTACCCCATGTGGAAGGCAGATGAGGAAACAGGCAAAGAAAGGCCATCTACAACCCACAGACTTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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