Basic Information
VIS ID
TVIS10013239
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
444
Orient
+
Integrated sequence
CTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTT| |CTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAG
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
138925813/138168243 (Hg38)
End
138925813/138168243 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-128-1/Upstream/2502765; hsa-mir-10b/Downstream/2418383;
Nearest TSS
ENST00000437798/Upstream/66359; ENST00000412593/Downstream/302413;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1402117, chr2-CpG: 71/Downstream/333220
Nearby gene
HNMT(-151879) ; SPOPL(+333537) ;
Upstream sequence
gcaatataccaaaatttctaagatacagcaaaactgtacctacctcaaaaagttggaaagatcccaaattaatgatctaacatcactactagaggaacta
Downstream sequence
gaaaatcaagaacaaactgaccccaaagctagcagaagaaaagaaataactaaaaccagagcagcaccaaatgaaagtgagaccccaaaatctatacaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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