Basic Information
VIS ID
TVIS10013251
Fusion event
HBV-ADGRF3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2681
Orient
+
Integrated sequence
TGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCAT| |TGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATA
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
26568784/26345916 (Hg38)
End
26568784/26345916 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRF3
Nearest miRNA
hsa-mir-1301/Upstream/1017195; hsa-mir-10b/Downstream/1650451;
Nearest TSS
ENST00000437798/Upstream/102; ENST00000462301/Downstream/170;
Nearest CpG islands
chr2-CpG: 87/Target, None/Upstream, None/Downstream
Upstream sequence
CCCCCGGGACCGGGAGCAAAGCCCGCTGGGAAATTGACCTTTCACCCCCTCTCTTGCCTTACCTCAGCTCACCAATTTTGACGCTAGCAAATGAAGCGAC
Downstream sequence
GAAGAGAGCTGGAAGGCGGGACTTAGTGTTGCCTGATCCACGCCGATTGGACAACAGCAGTGTCGGGGGACGGGCCGCTCGAGCGGGCTAGCAACCCCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate