Basic Information
VIS ID
TVIS10013253
Fusion event
HBV-LINC00486 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1535
Orient
+
Integrated sequence
GTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCT| |CTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCA
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
33141436/32916369 (Hg38)
End
33141436/32916369 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
LINC00486
Nearest miRNA
hsa-mir-1301/Upstream/281038; hsa-mir-10b/Downstream/502147;
Nearest TSS
ENST00000437798/Upstream/33568; ENST00000440786/Downstream/10758;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/288166, chr2-CpG: 164/Downstream/30012
Upstream sequence
ggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggagggaggggggggtgagagggggggggggggggggg
Downstream sequence
gggggggggggggggggggggggggggggggagggggggggggggggggggggggggggggggggggggggagggggggggggggggggggggggggggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate