Basic Information
VIS ID
TVIS10013256
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2707
Orient
+
Integrated sequence
AGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTAT| |CCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCT
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
17989382/18008738 (Hg38)
End
17989382/18008738 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA20A
Nearest miRNA
hsa-mir-103a-2/Upstream/7359043; hsa-mir-1-1/Downstream/461877;
Nearest TSS
ENST00000382410/Upstream/38681; ENST00000429853/Downstream/42001;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/39373, chr20-CpG: 167/Downstream/47482
Nearby gene
MGME1(-17620) ; OVOL2(+15414) ;
Upstream sequence
CAAAAACTGCATGACTGAATTAATGCAACAACAACAACAACAAATACatatatatatatatatattttttttttttttttaagagacggagtctctcttt
Downstream sequence
gtcgcccaggctggagtgcagtggcgtgatcttggctcaccgcaagctccacctcctggattcacgccattctgctgcctcagcctcccgagtagctggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate