Basic Information
VIS ID
TVIS10013259
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2479
Orient
-
Integrated sequence
ACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGG| |AACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAA
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
19797917/18425600 (Hg38)
End
19797917/18425600 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/1835275; hsa-mir-155/Downstream/260490;
Nearest TSS
ENST00000624081/Upstream/21944; ENST00000416002/Downstream/35131;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/180043, chr21-CpG: 89/Downstream/2571505
Nearby gene
TMPRSS15(-21947) ;
Upstream sequence
TTAAAAACATCTCTATTGCTGGAGAAATAATGGTTCTTTCACTTTCTTATGAGTTGTGTCCATTTCTGTGATGGTCTTACATGATATGTGAATGAATCAT
Downstream sequence
AAGTTATTCCTCAAACTCTTAACAAGTATTTATGTATCTGTGTAGATCAATAATTTAATTACCTGTGTAGAAATAAGAACTTATGAAAGCTTCAAATGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate