VISDB Viral Integration Site DataBase

VIS ID

TVIS10013260

Fusion event

HBV-ADARB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

371

Orient

-

Integrated sequence

TCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTA| |TCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCC

Chromosome

chr21

Cytoband

q22.3

Reference genome

Start

End

46587068/45167153 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-124-3p ; hsa-mir-34a-5p ; hsa-mir-148a-3p ; hsa-mir-93-5p ; hsa-mir-26b-5p ; hsa-mir-193b-3p ; hsa-mir-17-5p ; hsa-mir-218-5p ; hsa-mir-140-3p

Nearest miRNA

hsa-let-7c/Upstream/1557164; hsa-mir-6815/Downstream/311113;

Nearest TSS

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/32656, chr21-CpG: 22/Downstream/90651

Nearest cancer related gene

ADARB1(TSG, No orient, 0)

Upstream sequence

TAACCTTTGGTACAAGAGTTGGCATTCGTCAAAACTGAAAACGTTGGCTTCTGCTCTGCAAGAGATTTGTAGCTCCCATTCTTAATGTGGGCGGTACCTG

Downstream sequence

CAGGTACTCACCTGCCACCACACTCGGCATGACTATTTTCTACTGCGAGACATTTTCCATGTCCTTTTAAAAGAATTTTAATATGTAAGGGCAGGAAAAC