Basic Information
VIS ID
TVIS10013263
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2718
Orient
+
Integrated sequence
AAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCT| |AGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGG
Host Sequence
Chromosome
chr3
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
120249528/120530681 (Hg38)
End
120249528/120530681 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/134952; hsa-mir-12124/Downstream/518959;
Nearest TSS
ENST00000440867/Upstream/79428; ENST00000461682/Downstream/65628;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/79009, chr3-CpG: 49/Downstream/65430
Nearby gene
FSTL1(-79610) ; NDUFB4(+65600) ;
Upstream sequence
cattagcctgagtcgggatatgtgcccatctattaaccatcactgtggccaggagcatgggacatactgatgggcttaaggtaatcaggaATTGTGGCCA
Downstream sequence
acaggatttcaccatgttggccaggttggtctcgaatgcctgaccttaagtgatctacctgcctcggcctcccaaagttctgggattacaggcgtgagcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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