Basic Information
VIS ID
TVIS10013268
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2061
Orient
+
Integrated sequence
TTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACT| |GCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCA
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
55488973/55454945 (Hg38)
End
55488973/55454945 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/2608393; hsa-mir-12124/Downstream/397547;
Nearest TSS
ENST00000440867/Upstream/93116; ENST00000469484/Downstream/15196;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/828334, chr3-CpG: 24/Downstream/15228
Nearby gene
CACNA2D3(-380389) ; WNT5A(+10770) ;
Nearest cancer related gene
CACNA2D3(TSG, -380389) ; WNT5A(OG, +10770) ;
Upstream sequence
acagaaatacaaactaccatcagagaatactataaacacctctacacaaataaactagaaaatctagaagaaatggataaattcctcgacacatgcactc
Downstream sequence
acccactccaagcataaatgaatctgaatatccaagggacagcactagaatctgtactttaccaacatcctcgtcaattctgaagttctgtcaaatttgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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