Basic Information
VIS ID
TVIS10013274
Fusion event
HBV-LINC01396 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
+
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr4
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
4847540/4845813 (Hg38)
End
4847540/4845813 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01396
Nearest miRNA
hsa-mir-4800/Upstream/2595657; hsa-mir-12113/Downstream/1077462;
Nearest TSS
ENST00000502981/Upstream/1376; ENST00000468421/Downstream/13853;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/270092, chr4-CpG: 41/Downstream/7073
Nearby gene
STX18-AS1(-134876) ; MSX1(+13852) ;
Upstream sequence
gaaaagaaaggttaaactctgtgagttgaacgcacacatcaaaaagtagtttctgagaatgattctgtctaatttttatacgaagatatttctttttcta
Downstream sequence
gtatttttagtagagacagggtctcaccatgttagccaggctggtctcaatctcctgacctcagatgatccgccccccttggcctcccaaagtgctgaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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