Basic Information
VIS ID
TVIS10013277
Fusion event
HBV-ADGRL3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
+
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62623775/61758057 (Hg38)
End
62623775/61758057 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/835373; hsa-mir-1243/Downstream/4518767;
Nearest TSS
ENST00000502981/Upstream/170689; ENST00000508078/Downstream/137684;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/554974, chr4-CpG: 60/Downstream/1591072
Upstream sequence
ctaggttgtgtgctccttatgagaatctaatgcctgatgatctgtcactgtttcccaccacctagagatggaattatccagttgcaggaaaacaagtgca
Downstream sequence
gaataggtgcagtgtggtgcacagaagaatgtatattctattgatttgggatggagagttctgtagatgtctattaggtgcagagctgagttcaattcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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