Basic Information
VIS ID
TVIS10013281
Fusion event
HBV-CCDC192 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
277
Orient
-
Integrated sequence
TTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATT| |TTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTG
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
127135737/127800045 (Hg38)
End
127135737/127800045 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCDC192
Nearest miRNA
hsa-mir-10397/Upstream/8645329; hsa-mir-103a-1/Downstream/1297643;
Nearest TSS
ENST00000502646/Upstream/60507; ENST00000513708/Downstream/57759;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/281812, chr5-CpG: 200/Downstream/282857
Nearby gene
CTXN3(-141415) ;
Upstream sequence
gagagactaggaagggtctctttgagtagatgaaataggcagaaagtcctgaattttgagaaagaggtagctctgtaaagatctggagaatatatctgag
Downstream sequence
ttagatcactcgtcACACTCTGAAACCCATGATTTTGCTATTACAACTTGCTGTCTCTCCAAATTATATTCTCTATGTGCCATTTGAGGTATCAAATGGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate