Basic Information
VIS ID
TVIS10013284
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
+
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
13358967/13358855 (Hg38)
End
13358967/13358855 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/2880710; hsa-mir-103a-1/Downstream/1467074;
Nearest TSS
ENST00000502646/Upstream/183009; ENST00000503244/Downstream/412427;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/563320, chr5-CpG: 26/Downstream/451162
Nearby gene
LINC01194(-553672) ; DNAH5(+331470) ;
Upstream sequence
ACAGGAAGAAAATCTGGAACTACTGACAATGTAATGATTAAAAATGTGGAGTTAAAGCTCAAGAGGAATGCAAGCATATGCAATAACAACGCTCACACTT
Downstream sequence
gaacctctccgccccaatttatctgtaagacagggatgataatagtccatgcttcatggtattatttgagagaatgaaGACAATTTACTTCTAATAAGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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