Basic Information
VIS ID
TVIS10013289
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
-
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
60143467/60847640 (Hg38)
End
60143467/60847640 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5H
Nearest miRNA
hsa-mir-10397/Upstream/1143937; hsa-mir-103a-1/Downstream/11321827;
Nearest TSS
ENST00000502646/Upstream/3251; ENST00000457499/Downstream/19295;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/3102, chr5-CpG: 56/Downstream/97312
Nearby gene
ELOVL7(-3366) ; ERCC8(+26192) ;
Upstream sequence
AAAGCCTCCTAGGGAGGGAGCCAGGTCCACCAAGGCCAGAGACAGACAGGCGAGACTGTGGAAGGCCAGGGAGATGCTGCCTGGTAAGTGCTCAGCTGGC
Downstream sequence
aaactcctggtctcaagaacctccttcttcagcctcccaaagtgctgggattacaggtgtaaaccaccgtgcctggccTGGTATATGTATTTTTAAATTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate