Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013299
Fusion event
HBV-PURG integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|
Start
1863
Orient
+
Integrated sequence
AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACT| |GTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTT
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
Start
End
30881171/31023655 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-448 ; hsa-mir-5579-3p ; hsa-mir-5700 ; hsa-mir-1279 ; hsa-mir-6507-5p ; hsa-mir-92b-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-21-5p ; hsa-mir-590-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-186-5p ; hsa-mir-466 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-942-3p ; hsa-mir-4802-3p ; hsa-mir-3591-5p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-581 ; hsa-mir-100-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4662a-3p
Nearest miRNA
hsa-mir-124-1/Upstream/1066307; hsa-mir-10400/Downstream/10247393;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/111049, chr8-CpG: 109/Downstream/9189
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
AGGCTAAAAAAAACCCCCAAACCATTAGATGTTTAATCTTTGCATACCCTAGTAGTTACAAGTCCTCTAAAACAGAACCATACAGTTCACAGGTCAGTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.