Basic Information
VIS ID
TVIS10013306
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2904
Orient
-
Integrated sequence
CCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGT| |TGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATT
Host Sequence
Chromosome
chr9
Cytoband
q34.2
Reference genome
GRCh37/hg19
Start
137171972/134280126 (Hg38)
End
137171972/134280126 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/1228067; hsa-mir-126/Downstream/99285;
Nearest TSS
ENST00000422679/Upstream/111357; ENST00000484822/Downstream/15271;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/114521, chr9-CpG: 192/Downstream/45090
Nearby gene
RNU6ATAC(-142286) ; RXRA(+46344) ;
Upstream sequence
ttgcatccatgttcatcagggatattggtccaaaattctcttttttttgttgtgtctctgccaggctttggtatcaggatgatgctggcctcataaaagg
Downstream sequence
CCCCAGCAGCCCCCGGGAGTGGGGAGCGGTCTCCTCTGGAAGGGATCTCCCAGACTCCGGCGTCCTGGGCCTCCTGCAGGCCCAGGGGCTGCTCCTGTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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