Basic Information
VIS ID
TVIS10013308
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
108297737/109054507 (Hg38)
End
108297737/109054507 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/2414611; hsa-mir-105-1/Downstream/1000822;
Nearest TSS
ENST00000429181/Upstream/317967; ENST00000372107/Downstream/427565;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/317592, chrX-CpG: 30/Downstream/482318
Nearby gene
IRS4(-318130) ; GUCY2F(+318398) ;
Upstream sequence
ttaatactggcagaatcagtctaaaacagtctaCATTAATATTACTGAAAAAAGTAACCTTTTTCTTAAAACATTATTTGAATATTCAAGTAAAACCATT
Downstream sequence
aataccactactctgatcgttttttcactgacccggtgaggcgggggggcgagccctgaggggctctcgcttctggcgccaagcgcccggccgcacgcaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate