Basic Information
VIS ID
TVIS10013313
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2619
Orient
+
Integrated sequence
ATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAA| |AAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTA
Host Sequence
Chromosome
chrX
Cytoband
q12
Reference genome
GRCh37/hg19
Start
65327486/66107644 (Hg38)
End
65327486/66107644 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/88665; hsa-mir-105-1/Downstream/3915213;
Nearest TSS
ENST00000429181/Upstream/67519; ENST00000429547/Downstream/54905;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/285182, chrX-CpG: 27/Downstream/1436319
Nearby gene
VSIG4(-67519) ; HEPH(+54947) ;
Upstream sequence
ttcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcat
Downstream sequence
aatattgttgcctgatccttcctctggaagcttcgtctcagagaggcacccagttgtatgaggtgtgagtcagcccctactggcaggtgtctcccagtta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate