Basic Information
VIS ID
TVIS10013317
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2613
Orient
+
Integrated sequence
TCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAA| |TGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAA
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
3353560/3353562 (Hg38)
End
3353560/3353562 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-1227/Upstream/722769; hsa-let-7e/Downstream/607852;
Nearest TSS
ENST00000633603/Upstream/39159; ENST00000588839/Downstream/6001;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/38609, chr19-CpG: 313/Downstream/4935
Nearby gene
CELF5(-56487) ; NFIC(+6001) ;
Upstream sequence
gacagcataacaccccctctgccatatctaatcgtaggtcaatgggcaagcaaagcatcatacatccatacagttcaatccccatccccagtaaaagaat
Downstream sequence
gcacagtcatacacagaatcacatgaacaaatctcagataatgatgccgagtgaaagacaccggacactaaGAATGCTGCTGGCCCcagctatgctcatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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