Basic Information
VIS ID
TVIS10013324
Fusion event
HBV-LOC100129574 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1809
Orient
-
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
56417686/57121859 (Hg38)
End
56417686/57121859 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
LOC100129574
Nearest miRNA
hsa-mir-10397/Upstream/1612933; hsa-mir-103a-1/Downstream/1408184;
Nearest TSS
ENST00000502646/Upstream/150184; ENST00000513732/Downstream/52089;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/169335, chr5-CpG: 141/Downstream/51332
Nearby gene
MIER3(-169732) ; GPBP1(+52089) ;
Upstream sequence
TTTTGTAGACTAGCTGTTTGTTAATCAGTTTCTTTGTGTCTATTCATTATATGTGCTGTTCATGTCTAAAATGCCCATCATGTTTAAACACTGTGAAGCA
Downstream sequence
gctgaggcaggagaatcacttgaacctggaaggcagaggctgtagtgagctgagatcgtgccactgcactctagcctgagacagtgaaactctatctcaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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