Basic Information
VIS ID
TVIS10013325
Fusion event
HBV-ZFPM2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
106836106/105823878 (Hg38)
End
106836106/105823878 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
ZFPM2-AS1
Nearest miRNA
hsa-mir-12123/Upstream/1339413; hsa-mir-10400/Downstream/6819615;
Nearest TSS
ENST00000518652/Upstream/132988; ENST00000520870/Downstream/2692;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/503986, chr8-CpG: 19/Downstream/391679
Nearby gene
ZFPM2(-19339) ; OXR1(+446300) ;
Upstream sequence
ccatggaagaagttgctcaggcccaaagccttggagtcatctttgactctcctctgcacttacacccccatatcactctgcacctatcaaattaacctcc
Downstream sequence
GTGAGCTCtttttttttttttttttttttgagatggagtcttgctctgtcagcaggctggagtgcagtggcatgatctcagctcactgcaacctccactt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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