Basic Information
VIS ID
TVIS10013326
Fusion event
HBV-LOC101927506 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1574
Orient
-
Integrated sequence
CTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCG| |GACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACT
Host Sequence
Chromosome
chr8
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
155612/205612 (Hg38)
End
155612/205612 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101927506
Nearest miRNA
hsa-mir-10400/Downstream/1595513;
Nearest TSS
ENST00000518652/Upstream/38569; ENST00000610248/Downstream/26525;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/122118, chr8-CpG: 25/Downstream/23389
Nearby gene
OR4F21(-38588) ; RPL23AP53(+2733) ;
Upstream sequence
CCACTTTTATTTTTGGAGCTGTCTCTGACCTGTGAATCCTACAGTGAATACTCTTAAATATTTTAGTATCTGTCCAGATGATATTGGTACCCAGATCCTT
Downstream sequence
cccgaacccgaacccgaaccctaaccctaacccctaaccctaacccctaaccctaacccttaaccctaaccctaccccaaccccaaccctaacccctaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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