Basic Information
VIS ID
TVIS10013341
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
180
Orient
+
Integrated sequence
AACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTC| |CTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTC
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42535437/41704770 (Hg38)
End
42535437/41704770 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/6063518; hsa-mir-107/Downstream/1292793;
Nearest TSS
ENST00000439456/Upstream/3251589; ENST00000442306/Downstream/480569;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2761664, chr10-CpG: 184/Downstream/406263
Nearby gene
LOC441666(+291877) ;
Upstream sequence
ccatttctaagactggcctcaaatccctagaaatctccattggaaattgcacaaacagagtgtttgaaaactgctctttctaaaggaaggttcaactctg
Downstream sequence
ttagttgaatacacacaacacaaacaagttactgagaattcttctatctaacattatatgaagaaatcccgtttccaacgaaggcctcaaagaggtccaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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